Open Chemistry Journal




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Synthesis & Antifungal Screening of Novel Azetidin-2-ones



Apoorva Gupta*, Anand K. Halve
School of Studies in chemistry, Jiwaji University Gwalior-474011, India

Abstract

A new series of 4-[3-chloro-2-(4-hydroxy-3-methoxybenzyllidene)-4-oxoazetidin-1-yl]amino-N-(substituted)benzenesulfonamide, 4-{3-chloro-2-[5-methoxy-2-nitro-4-(prop-2-en-1-yloxy)benz yllidene]-4-oxoazetidin-1-yl}]amino}-N-(substituted)benzenesulfonamide and 4-{3-chloro-2-[4-hydroxy-3-methoxy-5-(prop-2-en-1-yl)benzylidene]-4-oxoazetidin-1-yl}amino}-N-(substituted) benzenesulfonamide were synthesized using appropriate synthetic route. The chemical structures of all the synthesized compounds were deduced on the basis of elemental analysis and spectroscopic data. The antifungal activity of the synthesized compounds was screened against several fungus. The synthesized compounds show potent antifungal activity against Aspergillus niger & Aspergillus flavus and significant structure-activity relationship (SAR) trends.

Keywords: Aspergillus flavus, Azetidin-2-ones, SAR.


Article Information


Identifiers and Pagination:

Year: 2015
Volume: 2
First Page: 1
Last Page: 6
Publisher Id: CHEM-2-1
DOI: 10.2174/1874842201502010001

Article History:

Received Date: 3/2/2015
Revision Received Date: 10/2/2015
Acceptance Date: 12/2/2015
Electronic publication date: 27/02/2015
Collection year: 2015

© Gupta and Halve; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the School of Studies in Chemistry, Jiwaji University Gwalior-474011, India; Tel: 8305962885; E-mail: apoorva.phd12@gmail.com



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