Open Chemistry Journal


ISSN: 1874-8422 ― Volume 8, 2021

Synthesis and Characterization of a Series of 1-Aryl-4-[aryldiazenyl]- piperazines. Part I. Isomers of N-(2,3-Dimethylphenyl)-N’-(Aryldiazenyl)- Piperazines

Chenguang Fan, Keith Vaughan*
Department of Chemistry, Saint Mary’s University, Halifax, Nova Scotia, B3H 3C3, Canada


This paper describes the synthesis of several new series of 1-(2-aryldiazen-1-yl-) 4-arylpiperazines and 1-(2- aryldiazen-1-yl-)4-arylalkylpiperazines by using diazonium coupling between arenediazonium ions with the appropriate 1-arylpiperazine or the 1-arylalkylpiperazine. The new compounds have a common thread in that they are isomers of the series of N-(2,3-dimethylphenyl)- N’-(aryldiazenyl)-piperazines. The new triazenes have been characterized by IR and NMR spectroscopy and mass spectrometry.

Keywords: Arylpiperazine; diazonium ion, 1-(2,3-dimethylphenyl-)piperazine, IR spectroscopy, Mass spectrometry, 1-(2- methylphenylmethyl-)piperazine, 1-(3-methylphenylmethyl-)piperazine, 1-(4-methylphenylmethyl-)piperazine, NMR spectroscopy, piperazine, triazene.

Article Information

Identifiers and Pagination:

Year: 2015
Volume: 2
First Page: 20
Last Page: 35
Publisher Id: CHEM-2-20
DOI: 10.2174/1874842201502010020

Article History:

Received Date: 2/2/2015
Revision Received Date: 6/4/2015
Acceptance Date: 7/4/2015
Electronic publication date: 30/10/2015

© Fan and Vaughan; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the (, which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Chemistry, Saint Mary’s University, Halifax, Nova Scotia, B3H 3C3, Canada; Tel: 902-420-5650; E-mail:

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