Open Chemistry Journal




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Piperine and Its Various Physicochemical and Biological Aspects: A Review



Bhawna Chopra1, 2, *, Ashwani Kumar Dhingra1, 2, Ram Prakash Kapoor1, Deo Nandan Prasad3
1 Guru Gobind Singh College of Pharmacy, Yamuna Nagar -135001, Haryana, India
2 I.K Gujral Punjab Technical University, Kapurthala-144603, Punjab, India
3 Shivalik College of Pharmacy, Nangal 140124, Punjab, India

Abstract

Piper nigrum L. is examined as the king of species worldwide by virtue of its principle piperine. In Ayurveda, since from the ancient times, it is known as “Yogvahi”. It is one of the important alkaloids of Pepper fruits (Family Piperaceae) and has been found to have numerous medicinal properties such as antioxidant, antiplatelet, anti-inflammatory, antihypertensive, hepatoprotective, antithyroid, antitumor, antiasthmatic activity and also have significant role as fertility enhancer. The present review discusses the biosynthetic pathway, extraction process, chemistry and various analytical methods of piperine. It also describes the structural modification of piperine and its various effects on biological system. The utility of piperine as a bioenhancer for certain antibacterial- antibiotics and a potent inhibitor of drug metabolism are also discussed. Thus, review provides knowledgeable erudition on the piperine which paves way for further work.

Keywords: Piperine, Bioenhancer, Biological activity, Piper nigrum.


Article Information


Identifiers and Pagination:

Year: 2016
Volume: 3
First Page: 75
Last Page: 96
Publisher Id: CHEM-3-75
DOI: 10.2174/1874842201603010075

Article History:

Received Date: 07/9/2015
Revision Received Date: 11/5/2016
Acceptance Date: 11/8/2016
Electronic publication date: 30/12/2016
Collection year: 2016

© Chopra et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Guru Gobind Singh College of Pharmacy, Yamuna Nagar -135001, Haryana, India; Tel: +91-9896151755, +91-9034051015; Fax: 01732-200381; E-mail: bhawna8486@gmail.com



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