Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack-753 003, Odisha, India
Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry.
Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs.
This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.
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