Open Chemistry Journal


ISSN: 1874-8422 ― Volume 8, 2021

Michael Addition of Imidazole to α, β -Unsaturated Carbonyl/Cyano Compound

Seetaram Mohapatra*, Nilofar Baral, Nilima Priyadarsini Mishra, Pravati Panda, Sabita Nayak
Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack-753 003, Odisha, India



Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry.


Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs.


This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.

Keywords: Michael addition, Imidazole derivative, Methyl acrylate, Silica sulfuric acid, Heterocycles, Ionic liquids.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 5
First Page: 18
Last Page: 31
Publisher Id: CHEM-5-18
DOI: 10.2174/1874842201805010018

Article History:

Received Date: 17/12/2017
Revision Received Date: 25/02/2018
Acceptance Date: 27/03/2018
Electronic publication date: 30/04/2018
Collection year: 2018

© 2018 Mohapatra et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack-753 003, Odisha, India, Tel: 7735675772; E-mail:

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