Open Chemistry Journal


ISSN: 1874-8422 ― Volume 8, 2021

Novel (N4) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity

Hanaa A. El-Boraey1, *, Ohyla A. EL-Gammal2
1 Department of Chemistry, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt
2 Department of Pathology, University Hospital, Menoufia University, Shebin El- Kom, Egypt



A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligand i.e. naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction.


The complexes have been characterized by elemental analysis, spectral (IR, UV–Vis, and ESR, molar conductivity, and magnetic as well as thermal analysis measurements.


On the basis of above studies, an octahedral geometry has been proposed for all complexes except Cu(II) nitrate complex that adopt square pyramidal geometry, and square planar geometry for Pd(II) chloride complex, respectively.


The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. Moreover, the in vitro antitumor activity of the some synthesized complexes against human breast and human hepatocarcinoma cell lines (MCF-7) and (HePG2), respectively has been studied.

Keywords: Tetra-azamacrocyclic, Macrocyclic metal complexes, Monobenzoylacetone, Spectral studies, Antitumor activity, IC50.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 5
First Page: 51
Last Page: 63
Publisher Id: CHEM-5-51
DOI: 10.2174/1874842201805010051

Article History:

Received Date: 20/02/2017
Revision Received Date: 10/05/2018
Acceptance Date: 31/05/2018
Electronic publication date: 29/06/2018
Collection year: 2018

© 2018 El-Boraey and El-Gammal.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Chemistry, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt; Tel: +20 111 7532777; Fax: +20 48 2235689.; E-mail:

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