Open Chemistry Journal


ISSN: 1874-8422 ― Volume 8, 2021

Evaluation of the Antioxidant Interactions Between Green Tea Polyphenols and Nonsteroidal Anti-inflammatory Drugs

Aleksandra Sentkowska1, Krystyna Pyrzynska2, *
1 Heavy Ion Laboratory, University of Warsaw, Pasteura 5A, 02-093 Warsaw, Poland
2 Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland



The antioxidant interactions between the commonly used pharmaceuticals (diclofenac, ibuprofen and naproxen) and green tea polyphenols were evaluated.


The antioxidant properties of the mixtures were evaluated by a scavenging effect on the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical.


The mixtures contained green tea extract and each drug exhibited lower antioxidant activity than the mathematical sum of the results obtained for individual components showing antagonistic effect. The results were obtained using isobolographic analysis and interaction factors also suggested the antagonistic type of interaction. Only when the concentration of the green tea infusion was relatively high (in comparison to the drug), an additive effect could be concluded.


The high concentration of green tea infusion in comparison to the drug should be used in developing the new formulations as it can help in the therapy due to their antioxidant properties.

Keywords: Green tea polyphenols, Nonsteroidal anti-inflammatory drugs, Isobolographic analysis, Interaction factor, Antioxidant, DPPH.

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 6
First Page: 47
Last Page: 51
Publisher Id: CHEM-6-47
DOI: 10.2174/1874842201906010047

Article History:

Received Date: 08/07/2019
Revision Received Date: 27/09/2019
Acceptance Date: 06/10/2019
Electronic publication date: 15/11/2019
Collection year: 2019

© 2019 Sentkowska and Pyrzynska

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland;

Track Your Manuscript:


I am completely satisfied with the service I received from Bentham Science Publishers, right from the submission of our research paper in ‘Open Chemistry’ to its publication in the journal. The reviewers' and editor's comments were very helpful in improving the paper.

I take this opportunity to express my appreciation to the whole team of BSP!

Dr. Arun Kumar Sharma
Govt. P.G. College,

Browse Contents

Webmaster Contact:
Copyright © 2023 Bentham Open