The Influence of HIV-1 Subtype in the Response to Therapeutic Dendritic Cell Vaccine

Ferreira, Valéria; Moura, Patrícia; Crovella, Sergio; Sobhie Diaz, Ricardo; Castelo Filho, Adauto; Ximenes, Ricardo; Arraes, Luiz Cláudio

The Influence of HIV-1 Subtype in the Response to Therapeutic Dendritic Cell Vaccine

Valéria Ferreira¹, Patrícia Moura², Sergio Crovella¹, Ricardo Sobhie Diaz^{*
, 3}, Adauto Castelo Filho³, Ricardo Ximenes³, Luiz Cláudio Arraes³

¹ Universidade Federal de Pernambuco, Recife (PE), Brazil

² Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, PE, Brazil

³ Paulista School of Medicine, Federal University of Sao Paulo, R. Pedro de Toledo, 781, Sao Paulo, SP – 04039-000, Brazil

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 6
First Page: 289
Last Page: 292
Publisher ID: TOAIDJ-6-289
DOI: 10.2174/1874613601206010289

Article History:

Received Date: 20/1/2012
Revision Received Date: 10/6/2012
Acceptance Date: 12/6/2012
Electronic publication date: 14/12/2012
Collection year: 2012

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© Ferreira et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Paulista School of Medicine, Federal University of Sao Paulo, R. Pedro de Toledo, 781, Sao Paulo, SP – 04039-000, Brazil; Tel: (55-11) 9109-0445; Fax: (55-11) 4192-3176; E-mail: rsdiaz@catg.com.br

In the present study, we investigated the influence of HIV-1 subtype in the response to the dendritic cell (DC) therapeutic vaccine for HIV. HIV-1 viral load and TCD8+/TCD4+ cell counts for up to 48 weeks after vaccination. Out of 19 immunized subjects, 13 were infected by subtype B, 5 by subtype F, and 1 by subtype D. Overall, 42.1% (8/19) achieved a viral load decline of ≥ 1 log₁₀ sustained up to 48 weeks after immunization. Such magnitude of viral load drop was seen in 80% (4/5) of subtype F infected patients, and in 23.0% (3/13) of the subtype B infected ones (p=0.08). Moreover, mean viral load decline was 1.32 log₁₀, for subtype F infected individuals compared to 0.5 log₁₀ among subtype B infected patients (p=0.01). The variation in TCD4+ cell count was not related to HIV-1 subtype. Larger studies are necessary to confirm the efficacy of this immunotherapy and the differential response according to the background genetic diversity of HIV-1.

Keywords: Dendritic cells, HIV-1 subtype, vaccine, immunotherapy..

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RESEARCH ARTICLE

The Influence of HIV-1 Subtype in the Response to Therapeutic Dendritic Cell Vaccine

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