The Open Anesthesia Journal

Formerly: The Open Anesthesiology Journal

ISSN: 2589-6458 ― Volume 15, 2021

The Effects of Glycopyrrolate as Premedication on Post-Operative Nausea and Vomiting: A Propensity Score Matching Analysis

Seunghyuk Lee1, Sang W. Yoon1, Geun J. Choi1, Yong-Hee Park1, Hyun Kang1, *, Chong W. Baek1, Yong Hun Jung1, Young C. Woo1
1 Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, 84 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea



Glycopyrrolate is often used as a premedication for anesthesia as it has anti-sialogogue and vagolytic effect. Patients undergoing laparoscopic gynecologic surgery have high-risk of Post-Operative Nausea and Vomiting (PONV).


This retrospective study investigates the effect of glycopyrrolate as a premedication for PONV in patients receiving fentanyl-based Intravenous (IV) Patient-Controlled Analgesia (PCA) after laparoscopic gynecological surgery.


We reviewed the medical records of adult patients who received fentanyl-based IV-PCA after laparoscopic gynecological surgery at Chung-Ang University Hospital between January 1, 2010, and June 30, 2016. We classified patients into two groups on the basis of glycopyrrolate premedication: non-premedicated group (Group N; n = 316) and glycopyrrolate premedicated group (Group P; n = 434). The Propensity Score Matching Method (PSM) was used to select 157 subjects in Group N and P, on the basis of their covariates which were matched with a counterpart in the other group.


Prior to PSM, the necessities for rescue anti-emetics were lower on Postoperative Day (POD) 0 (58[18.4%] vs. 45[10.4%], P = 0.002) and POD1 (60[19.0%] vs. 59[13.6%], P = 0.046), and Visual Analogue Scale (VAS) of pain on POD 1 (2.86 ± 1.49 vs. 3.13 ± 1.53, P = 0.017) was higher in group P. After PSM, the Numerical Rating Scale (NRS) score for nausea (0.38 ± 0.75 vs. 0.21 ± 0.62, P = 0.027) and rescue anti-emetics (27 [17.2%] vs. 15 [9.6%], P = 0.047) on POD 0 were both lower in the group P.


In patients receiving fentanyl-based IV-PCA after laparoscopic gynecological surgery, the severity of nausea and necessity for rescue ant-emetic was lower in the glycopyrrolate premedication group.

Keywords: Analgesia, Patient-controlled, Gynecologic surgical procedures, Laparoscopy, Postoperative nausea and vomiting, Glycopyrrolate.

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 93
Last Page: 99
Publisher Id: TOATJ-13-93
DOI: 10.2174/2589645801913010093

Article History:

Received Date: 28/06/2019
Revision Received Date: 16/08/2019
Acceptance Date: 1/09/2019
Electronic publication date: 30/09/2019
Collection year: 2019

© 2019 Lee et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Anesthesiology and Pain Medicine Chung-Ang University College of Medicine 84 Heukseok-ro, Dongjak-gu Seoul, 06911, Republic of Korea; Tel: +82-2-6299-2571, 2579, 2586; Fax: +82-2-6299-2585; E-mail:

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