The Open Biomaterials Journal




(Discontinued)

ISSN: 1876-5025 ― Volume 5, 2014

Comparative Study of Sr+2 and Zn+2 Incorporation in the Biomimetic Coating of a Prosthetic Alloy



Wafa I Abdel-Fattah*, 1, El-Sayed M El-Sayed2, Mona S Talaat2, Alaa Adawy§1, 2
1 Biomaterials Department, National Research Centre, 12311 Dokki, Cairo, Egypt
2 Physics Department, Faculty of Science, Ain-Shams University, 11566 Abbassia, Cairo, Egypt

Abstract

The next great wave of innovation and development for implantable medical devices focuses on surface engineering. This would enhance their performance, restore lost functions and ultimately reduce pain. Biomimetic coating is a promising approach, used in that concern. In the present work, an attempt was made to develop the function of the biomimetic coating rather than the classical biocompatibility. Corrected simulated body fluid, leading the conventional fluid concentration by one half, 1.5 × c-SBF, was prepared with adequate supplement of Sr+2, or Zn+2 according to the permissible therapeutic doses, 0.5 mM. The selection of Sr+2 and Zn+2 as additives was owing to their anti-osteoporotic and antimicrobial/bacterial activity respectively. The bioinert discs of titanium aluminum vanadium alloy, Ti-6Al-4V, were pretreated according to our previously developed protocol [Alaa Adawy et al. 2009, Biomimetic Coating of Precalcified Ti-6Al-4V Alloy, J. Open Medical Devices, 1(2009)19]. Subsequently, they were soaked in the prepared SBFs. Stepwise surface characterization was assessed using Diffuse Reflectance Infra-red Fourier Transform Spectroscopy, DRIFTS. In parallel, the remnants of the soaking solutions were analyzed chemically by atomic absorption and biochemical kits, and physically by AC electrical conductivity measurements at room temperature. Scanning electron microscopy, SEM, was used to assess surface final morphology post the whole treatment duration. Incorporation of Sr+2 and Zn+2 resulted in the growth of calcium deficient apatite of high carbonate content. The former increased the activity of biomimetic deposition while the latter induced more uniformity in the resultant coating.

Keywords: Biomimetic, Ti-6Al-4V, strontium, zinc, DRIFTS, electrical conductivity.

Article Information


Identifiers and Pagination:

Year: 2011
Volume: 3
First Page: 4
Last Page: 13
Publisher Id: TOBIOMTJ-3-4
DOI: 10.2174/1876502501103010004

Article History:

Received Date: 25/5/2009
Revision Received Date: 24/11/2010
Acceptance Date: 3/12/2010
Electronic publication date: 23/9/2011
Collection year: 2011

© Abdel-Fattah et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Biomaterial Department, National Research Center, 12311 Dokki, Cairo, Egypt; Tel: 00202-33371414; Fax: 00202- 33370931; E-mail: nrcfifi@yahoo.com§ Current Address: Solid State Chemistry department, IMM institute, Faculty of Science, Radboud University Nijmegen, 6525 AJ Nijmegen, Netherlands



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