REVIEW ARTICLE
Effect of BMP-2 on Gene Expression of Enamel Matrix Proteins at the Dental Epithelial Cell Line
Liming Xu1, Ryoya Takahashi2, Hidemitsu Harada3, Akiyoshi Taniguchi*, 1
Article Information
Identifiers and Pagination:
Year: 2007Volume: 1
First Page: 18
Last Page: 20
Publisher ID: TOBIOTJ-1-18
DOI: 10.2174/1874070700701010018
Article History:
Received Date: 11/06/2007Revision Received Date: 18/06/2007
Acceptance Date: 18/06/2007
Electronic publication date: 4/7/2007
Collection year: 2007
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Epithelial-mesenchymal interactions play an important role in the control of ameloblasts and odentoblasts differentiation, and the bone morphogenetic proteins (BMPs) are known factors that regulate the differentiation of ameloblasts. We examined the effect of BMP-2 on the expression of the enamel matrix protein genes at the dental epithelial cell line. BMP-2 induced a 3- to 4-fold increase in amelogenin and ameloblastin mRNA expression, suggesting that BMP-2 is important for ameloblast differentiation. This finding has potential application in the tissue engineering of tooth re-constructions.