A quartz crystal microbalance was used for real-time monitoring of fibrinogen cross-linking on three model
biomaterial surfaces. Fibrinogen adsorbs slowly and forms a less rigid multi-layer on hydrophobic surfaces, while it adsorbs
quickly, forming a single mono-layer on hydrophilic surfaces. The extent of fibrinogen cross-linking is greater on
hydrophobic surfaces. Fibrinogen cross-linking can also rigidify the relatively soft coatings of poly(methyl methacrylate)
and dodecanethiol self-assembled monolayer.