REVIEW ARTICLE
Real-Time Monitoring of Fibrinogen Cross-Linking on Model Biomaterial Surfaces with Quartz Crystal Microbalance
Brian C. Heinze, Jeong-Yeol Yoon*
Article Information
Identifiers and Pagination:
Year: 2008Volume: 2
First Page: 247
Last Page: 251
Publisher ID: TOBIOTJ-2-247
DOI: 10.2174/1874070700802010247
Article History:
Received Date: 24/06/2008Revision Received Date: 08/10/2008
Acceptance Date: 05/11/2008
Electronic publication date: 21/11/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
A quartz crystal microbalance was used for real-time monitoring of fibrinogen cross-linking on three model biomaterial surfaces. Fibrinogen adsorbs slowly and forms a less rigid multi-layer on hydrophobic surfaces, while it adsorbs quickly, forming a single mono-layer on hydrophilic surfaces. The extent of fibrinogen cross-linking is greater on hydrophobic surfaces. Fibrinogen cross-linking can also rigidify the relatively soft coatings of poly(methyl methacrylate) and dodecanethiol self-assembled monolayer.