The Open Dentistry Journal




ISSN: 1874-2106 ― Volume 13, 2019
RESEARCH ARTICLE

Evaluation of Effect of Surgical and Nonsurgical Periodontal Therapy on Serum C-Reactive Protein, Triglyceride, Cholesterol, Serum Lipoproteins and Fasting Blood Sugar in Patients with Severe Chronic Periodontitis



Amir Moeintaghavi1, Hamid Reza Arab2, Masoud Amiri Moghaddam2, Reza Shahmohammadi3, *, Bahareh Yalood Bardan4, Zahra Soroush4
1 Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Periodontology, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Endodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
4 Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background:

Cardiovascular disease has been associated with multiple risk factors such as dyslipidemia. However, the focus has recently shifted towards some novel risk factors i.e. infection from periodontitis.

Given this background, we aimed to assess the effect of periodontal therapy on some CVD risk factors including Total Cholesterol (TC), Low-Density Lipoprotein(LDL), High-Density Lipoprotein(HDL), Triglycerides(TG) and C-Reactive Protein (CRP). Fasting Blood Sugar (FBS) level has also been measured.

Methods:

Thirty patients (12 male and 18 female) who had severe periodontitis were tested for different blood parameters; namely Total Cholesterol (TC), Low-Density Lipoprotein (LDL), High-Density Lipoprotein(HDL), Triglycerides (TGs), C-Reactive Protein (CRP) and Fasting Blood Sugar (FBS). Enzymatic colorimetric methods were applied to measure all the parameters’ values except for CRP. The first stage of periodontal treatment comprised oral hygiene instruction as well as scaling and root planing. After 1 month, at the next stage, open flap debridement surgery was performed on all 4 quadrants of the mouth. The blood parameters were reassessed and compared with the baseline values after 3 months. Two patients (female) failed to participate in the follow-ups. The Pearson's and Spearman's correlation coefficients were calculated to determine whether changes in laboratory variables are associated with age and average probing depth or not.

Results:

All the assessed parameters related to 28 patients showed mean reduction which proved to be significant for CRP (p=0.011) and cholesterol (p=0.035). Among all parameters, only CRP level was found to have a significant positive correlation with pocket depth. Other blood parameters' relationship with age and probing depth proved to be insignificant.

Conclusion:

Considering the results, periodontal treatment may significantly lower lipid profile serum levels and some inflammatory factors.

Keywords: Dyslipidemia, Periodontitis, Cardiovascular diseases, Periodontal diseases, Immunoturbidimetry, Periodontal pocket.


Article Information


Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 15
Last Page: 21
Publisher Id: TODENTJ-13-15
DOI: 10.2174/1874210601913010015

Article History:

Received Date: 28/07/2018
Revision Received Date: 23/11/2018
Acceptance Date: 11/12/2018
Electronic publication date: 31/1/2019
Collection year: 2019

Article Metrics:

CrossRef Citations:
0

Total Statistics:

Full-Text HTML Views: 1448
Abstract HTML Views: 1226
PDF Downloads: 394
ePub Downloads: 283
Total Views/Downloads: 3351

Unique Statistics:

Full-Text HTML Views: 835
Abstract HTML Views: 622
PDF Downloads: 255
ePub Downloads: 167
Total Views/Downloads: 1879
Geographical View

© 2019 Moeintaghavi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Department of Endodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran; Tel: +989153115176; Fax: 9177948959; E-mail: drezashahm@gmail.com



Endorsements



"Thank you for your magnificent and marvelous support throughout the publication stages. I would like to endorse my experience with you as a Junior Researcher and a recent graduate of the Dental school. Once again Thank you for your Great Help and Guidance throughout the stages of Publication. You guys are a great team and I am proud to be a Young Bentham author."


Asra Sabir Hussain
The University of Edinburgh Business School, UK

"My experience with Bentham Open was a valuable one because the quality of the services and analysis of my paper contributed in improving what we intended to convey to the readers."


José Ricardo Kina
Department of Surgery and Integrated Clinic,
Araçatuba School of Dentistry, São Paulo State University
Brazil

"The Publication Manager was very cooperative and replied my mails and guided me without any delays; however the reviewing process was too long."


Mahtab Memarpour
Prevention of Oral and Dental Disease Research Center,
Department of Pediatric Dentistry, School of Dentistry,
Shiraz University of Medical Sciences, Shiraz,
Iran


Browse Contents



Webmaster Contact: info@benthamopen.net
Copyright © 2019 Bentham Open