The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 14, 2020

In vitro Assessment of Peri-implantitis Treatment Procedures: A Review

Merve Benli1, 2, Catherine Petit2, 3, Henri Tenenbaum2, 3, Olivier Huck2, 3, *
1 Department of Prosthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey
2 Regenerative Nanomedicine , Fédération de Médecine Translationnelle de Strasbourg (FMTS), INSERM 1260, Strasbourg, France
3 Department of Periodontology, Faculté de Chirurgie-Dentaire, Université de Strasbourg, Strasbourg, France



The prevalence of peri-implantitis is increasing continuously and such a biological complication significantly decreases implant survival and success. Although various treatment modalities have been identified for peri-implantitis, no completely efficient method has yet been established.


The aim of this review was to evaluate the scientific literature regarding the in vitro effects of peri-implantitis treatment.


A review of the literature was performed by using Google Scholar, PubMed/ MEDLINE and Science Direct databases. In vitro studies on peri-implantitis treatment modalities were selected. The search strategy identified 57 eligible studies. After selection, 21 articles met all the inclusion criteria and were included in the present review.


Included in vitro studies evaluated different types of peri-implantitis treatment modalities such as mechanical, chemical, combination and laser therapies. Combination therapies with the aid of adjuvants were found to be more effective compared to the studies that used only one type of treatment modality. Laser systems were also tested and displayed interesting results in terms of surface decontamination with a variability associated with selected parameters.


This review was performed to evaluate the efficacy of the treatment modalities used for peri-implantitis in vitro. Although there are various effective treatment methods, none has been completely successful in removing the biofilms related to peri-implantitis. The findings imply the need for further studies to develop more effective antimicrobial treatment procedures.

Keywords: Biofilm, Peri-implantitis, Laser, Titanium, Implant, Mucositis.

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 267
Last Page: 273
Publisher Id: TODENTJ-13-267
DOI: 10.2174/1874210601913010267

Article History:

Received Date: 21/05/2019
Revision Received Date: 11/07/2019
Acceptance Date: 26/07/2019
Electronic publication date: 31/07/2019
Collection year: 2019

© 2019 Benli et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Dental Faculty, Université de Strasbourg, 8 rue Sainte-Elisabeth, 67000 Strasbourg, France;

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