The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 14, 2020

The Role of TNF-α as a Proinflammatory Cytokine in Pathological Processes

Luciano B. Silva1, Alexandrino P. dos Santos Neto2, *, Sandra M.A.S. Maia1, Carolina dos Santos Guimarães1, Iliana L. Quidute1, Alessandra de A.T. Carvalho2, Severino A. Júnior3, Jair C. Leão2
1 Departament of Endodontics, University of Pernambuco (UPE), 1650 Gal Ne wton Cavalcanti Avenue, Camaragibe, PE, Brazil 54753-020
2 Department of Clinical and Preventive Dentistry, Health Sciences Center, Federal University of Pernambuco (UFPE), 1235 Prof. Moraes Rego Street, Recife, PE, Brasil 50670901
3 Department of Fundamental Chemistry, Exact and Nature Sciences Center, Federal University of Pernambuco (UFPE), Prof. Luis Freire Street, Recife, PE, Brasil 50740-540


TNF-α is a member of the vast cytokine family being considered a proinflammatory substance produced many by macrophages and other cells belonging to the innate immunity, many of them classified as indeed Antigen Presenting Cells (APCs) involved in the complex chemotactic process of activation of the adaptive immunity. The aim of this work was to accomplish a literature review concerning the main pathologies that have TNF-α as a modulating agent in other to bring light to the main interactions present in the inflammation installed.

Keywords: Tumor necrosis factor, Inflammation, Cytokine(s), Leucocytes, Antigen Presenting Cells (APCs), Interferon (IFN).

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 332
Last Page: 338
Publisher Id: TODENTJ-13-332
DOI: 10.2174/1874210601913010332

Article History:

Received Date: 26/12/2018
Revision Received Date: 11/07/2019
Acceptance Date: 25/08/2019
Electronic publication date: 30/09/2019
Collection year: 2019

© 2019 Silva et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Department of Clinical and Preventive Dentistry, Health Sciences Center, Federal University of Pernambuco (UFPE), 1235 Prof. Moraes Rego Street, Recife, PE, Brasil, 50670901, Tel: +55-81-21268818; Fax: +55-81-21268818; E-mail:

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