The Open Dentistry Journal

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Evaluation of In-office Vital Tooth Whitening Combined with Different Concentrations of At-home Peroxides: A Randomized Double-blind Clinical Trial

Leandro Féliz-Matos1, *, Ninoska Abreu-Placeres1, Luis Miguel Hernandez1, Carlos Ruiz-Matuk2, Patricia Grau-Grullón1
1 Biomaterials and Dentistry Research Center, Academic Research Department, Universidad Iberoamericana, Santo Domingo, Dominican Republic
2 Department of Statistics - Universidad Iberoamericana (UNIBE), Santo Domingo, Dominican Republic



The clinical evidence relate the effect of associating the in-office and at home vital tooth whitening, describing positive effects on tooth color change and reduction of dental sensitivity.


The purpose of this randomized double-blind clinical trial was to evaluate the effect on the shortened application of in-office vital tooth whitening combined with different concentrations of at-home peroxides in the final tooth color change and dental sensitivity.


Randomized double-blind clinical trial with 120 participants between 18-65 years, allocated in four tooth whitening treatment groups: G1= Carbamide Peroxide 10% + Hydrogen Peroxide 40%, G2= Carbamide Peroxide 15% + Hydrogen Peroxide 40%, G3= Carbamide Peroxide 20% + Hydrogen Peroxide 40%, G4= Hydrogen Peroxide 10% + Hydrogen Peroxide 40% was conducted. Tooth color was measured at baseline and dental sensitivity and tooth color change during and after treatment.


No statistical significant differences were found in tooth color change (superior arch p= 0.183 / inferior arch p= 0.374), and in dental sensitivity (p=0.268).


Reducing the application time of in-office whitening, combined with in-home products was effective in improving the color. All groups resulted in identical final color change and dental sensitivity. NCT02682329 Available from:

Keywords: Hydrogen peroxide, Carbamide peroxide, Tooth whitening, Dental sensitivity, Tooth bleaching, Dental Esthetics.

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 377
Last Page: 382
Publisher Id: TODENTJ-13-377
DOI: 10.2174/1874210601913010377

Article History:

Received Date: 22/05/2019
Revision Received Date: 30/08/2019
Acceptance Date: 13/10/2019
Electronic publication date: 15/11/2019
Collection year: 2019

© 2019 Feliz-Matos et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Biomaterials and Dentistry Research Center (CIBO-UNIBE), Academic Research Department, Universidad Iberoamericana, Avenida Francia #129 - Gascue, Santo Domingo, Dominican Republic Tel: (809) 689-4111 Ext. 1501; Fax: (809) 731-2904;

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