The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 14, 2020

Manifestations in the Oral Mucosa of Erythromelalgia. A Case Report

Nansi López-Valverde1, Antonio López-Valverde1, *, Juan M Ramírez 2, Rafael Gómez de Diego3
1 Department of Surgery, Faculty of Medicine, School of Dentistry, University of Salamanca, Salamanca, Spain
2 Department of Morphological Sciences. School of Medicine, University of Córdoba, Córdoba, Spain
3 Department of Stomatology, School of Odontology, University Rey Juan Carlos, Madrid, Spain



Erythromelalgia or erythermalgia, is a peripheral paroxysmal vascular disease of the distal extremities, although it can also affect the face, ears and knees. It is characterized by increased skin temperature, erythema and intermittent episodes of burning pain. Likewise, it can also be characterized by lesions of the oral mucosa.

Case report:

Here we present the case of a 6-year old female with EM presenting ulcerative and scaly lesions in the oral cavity and whitish linear branching ulcerative lesions on the tongue. Fabry disease and rheumatoid conditions were ruled out and there were no mutations in SCN9A gene. Treatment with voltage-gated sodium channel blockers (oxcarbacepine-Trileptal®) and anticonvulsants (Perampanel-Fycompa®) did not improve pain symptoms, however, performing moderate physical activity, use of comfortable footwear, and local application of cold resulted in the restoration of patient´s quality of life


To our knowledge, this report described for the first time, the successful treatment of ulcerative lesions of the oral mucosa in Erythromelalgia. We believe that the treatments described here (exercise, comfortable footwear and local application of cold) could improve the quality of life of Erythromelalgia patients.

Keywords: Erythromelalgia, Erythermalgia, Ulcerative lesion, Whitish lesion, Oral mucosa, Rheumatoid conditions, Fabry disease.

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 61
Last Page: 66
Publisher Id: TODENTJ-13-61
DOI: 10.2174/1874210601913010061

Article History:

Received Date: 20/11/2018
Revision Received Date: 02/01/2019
Acceptance Date: 24/01/2019
Electronic publication date: 28/02/2019
Collection year: 2019

© 2019 López-Valverde et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Clínica Odontológica. C/Alfonso X el Sabio, S/N. Campus Miguel de Unamuno. Salamanca, Salamanca. 37007. Spain; Tel: 0034 923294500- Ext 1996; E-mail:

Track Your Manuscript:


"Thank you for your magnificent and marvelous support throughout the publication stages. I would like to endorse my experience with you as a Junior Researcher and a recent graduate of the Dental school. Once again Thank you for your Great Help and Guidance throughout the stages of Publication. You guys are a great team and I am proud to be a Young Bentham author."

Asra Sabir Hussain
The University of Edinburgh Business School, UK

"My experience with Bentham Open was a valuable one because the quality of the services and analysis of my paper contributed in improving what we intended to convey to the readers."

José Ricardo Kina
Department of Surgery and Integrated Clinic,
Araçatuba School of Dentistry, São Paulo State University

"The Publication Manager was very cooperative and replied my mails and guided me without any delays; however the reviewing process was too long."

Mahtab Memarpour
Prevention of Oral and Dental Disease Research Center,
Department of Pediatric Dentistry, School of Dentistry,
Shiraz University of Medical Sciences, Shiraz,

Browse Contents

Webmaster Contact:
Copyright © 2020 Bentham Open