The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 14, 2020

Bioinformatics and Data Mining Studies in Oral Genomics and Proteomics: New Trends and Challenges

Luca Giacomelli*, Ugo Covani
Tirrenian Stomatologic Institute, Via Aurelia 335, Lido di Camaiore (Lucca), Italy


Genomics and proteomics have promised to change the practice of dentistry and oral pathology, allowing the identification and the characterization of risk factors and therapeutic targets at a molecular level. However, mass-scale molecular genomics and proteomics suffer from some pitfalls: gene/protein expression are significant only if inserted in a detailed network of molecular pathways and gene/gene, gene/protein and protein/protein interactions.

The proper analysis of these complex pictures requires the contribution of theoretical disciplines, like bioinformatics and data mining. In particular, data-mining of existing information could become a strong starting point to formulate new targeted hypotheses and to plan ad hoc experimentation.

In this review, advantages and disadvantages of the above-mentioned disciplines and their potential in oral pathology are discussed. The leader gene approach is a new data mining algorithm, recently applied to some oral diseases and their correlation with systemic conditions. The preliminary results of the application of the leader gene approach to the correlation between periodontitis and heart ischemia at a molecular level are presented for the first time.

Keywords: Bioinformatics, data mining, gene interaction, genomics, heart ischemia, oral diseases, periodontitis, proteomics.

Article Information

Identifiers and Pagination:

Year: 2010
Volume: 4
First Page: 67
Last Page: 71
Publisher Id: TODENTJ-4-67
DOI: 10.2174/1874210601004010067

Article History:

Received Date: 2/9/2009
Revision Received Date: 1/10/2009
Acceptance Date: 1/10/2009
Electronic publication date: 16/7/2010
Collection year: 2010

© Giacomelli and Covani; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Tirrenian Stomatologic Institute, Via Aurelia 335, Lido di Camaiore (Lucca), Italy; Tel: +39 02 87 28 00 09; Fax: +39 02 56 93 314; E-mail:

Track Your Manuscript:


"Thank you for your magnificent and marvelous support throughout the publication stages. I would like to endorse my experience with you as a Junior Researcher and a recent graduate of the Dental school. Once again Thank you for your Great Help and Guidance throughout the stages of Publication. You guys are a great team and I am proud to be a Young Bentham author."

Asra Sabir Hussain
The University of Edinburgh Business School, UK

"My experience with Bentham Open was a valuable one because the quality of the services and analysis of my paper contributed in improving what we intended to convey to the readers."

José Ricardo Kina
Department of Surgery and Integrated Clinic,
Araçatuba School of Dentistry, São Paulo State University

"The Publication Manager was very cooperative and replied my mails and guided me without any delays; however the reviewing process was too long."

Mahtab Memarpour
Prevention of Oral and Dental Disease Research Center,
Department of Pediatric Dentistry, School of Dentistry,
Shiraz University of Medical Sciences, Shiraz,

Browse Contents

Webmaster Contact:
Copyright © 2020 Bentham Open