The Open Dentistry Journal

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Retention Loss of Resin Based Fissure Sealants - a Valid Predictor for Clinical Outcome?

Steffen Mickenautsch*, Veerasamy Yengopal
SYSTEM Initiative/Department of Community Dentistry, Faculty of Health Sciences, University of the Witwatersrand - 7 York Rd., Parktown/Johannesburg 2193, South Africa



The null-hypothesis that retention loss of resin fissure sealants predicts caries manifestation no more accurately than random values was tested.


Systematic reviews were checked and electronic databases searched for clinical trials. Trials reporting on the retention of resin sealants and caries occurrence in permanent molar teeth, with minimum 24-month follow-up period, were included. Extracted data: number of sealed teeth, number of teeth without completely retained sealants, number of sealed teeth with caries. The number of teeth with complete sealant retention and absence of carious lesions/cavities was calculated; the predictive outcomes: true/false positive; false/true negative were established. Random values were generated as control-data. Diagnostic Odds ratios (DOR) were computed and tested for statistical difference. Summary Receiver Operating Characteristic curves were plotted.


95 trials were found. Median DOR values were 1.21 and 0.28 for test- and control data, respectively. Wilcoxon test (z = 0.56; p = 0.58) and Sign test (z = 1.38; p = 0.17) results were statistically non-significant. The null-hypothesis was not rejected.


Predictions based on the retention loss of resin sealants, regarding caries manifestation, was no more accurate than random guesses. Sealant retention loss appears not to be a valid predictor for clinical outcome.

Keywords: : Diagnostic Odds ratio, fissure sealant, resin, retention, surrogate endpoint, tooth caries.

Article Information

Identifiers and Pagination:

Year: 2013
Volume: 7
First Page: 102
Last Page: 108
Publisher Id: TODENTJ-7-102
DOI: 10.2174/18742106201305130001

Article History:

Received Date: 1/3/2013
Revision Received Date: 25/4/2013
Acceptance Date: 28/4/2013
Electronic publication date: 23/8/2013
Collection year: 2013

© Mickenautsch and Yengopal; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the SYSTEM Initiative/Department of Community Dentistry, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd., Parktown/Johannesburg, 2193, South Africa; Tel: +27 11 717 2594; Fax: +27 11 717 2625; E-mail:

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