The Open Dentistry Journal

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A Keratocyst in the Buccal Mucosa with the Features of Keratocystic Odontogenic Tumor

Kazuhiko Yamamoto*, Yumiko Matsusue, Miyako Kurihara, Yuka Takahashi , Tadaaki Kirita
Department of Oral and Maxillofacial Surgery, Nara Medical University


A 74-year-old male patient consulted us for an elastic firm mass in the right buccal mucosa. CT examination revealed a well-circumscribed oval cystic lesion in the anterior region of the masseter muscle. On MRI, the lesion showed a low signal on T1-weighted image and a high signal on T2-weighted image. Aspiration biopsy demonstrated the presence of squamous cells in whitish liquid. Under the diagnosis of epidermoid cyst, the lesion was intraorally extirpated under general anesthesia. The lesion was cystic at the size of 30 × 25mm. Histologically, the cyst wall was lined with parakeratinized squamous epithelium corrugated on its surface, the basal layer of which consisted of cuboidal cells showing palisading of the nuclei. Immunohistochemically, the lining epithelium was positive for CK17 and negative for CK10. The basal and suprabasal cells were labeled for Ki-67 at a relatively high rate. These features are compatible with those of keratocystic odontogenic tumor.

Keywords: : Buccal mucosa, cutaneous keratocyst, epidermoid cyst, keratocystic odontogenic tumor, nevoid basal cell carcino-ma syndrome, parakeratinization.

Article Information

Identifiers and Pagination:

Year: 2013
Volume: 7
First Page: 152
Last Page: 156
Publisher Id: TODENTJ-7-152
DOI: 10.2174/1874210601307010152

Article History:

Received Date: 16/7/2013
Revision Received Date: 30/9/2013
Acceptance Date: 1/10/2013
Electronic publication date: 13/11/2013
Collection year: 2013

© Yamamoto et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan; Tel/Fax: +81-744-29-8875; E-mail:

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