REVIEW ARTICLE


Therapeutic Potential of Prodrugs Towards Targeted Drug Delivery



Abhinav P. Mishra*, Suresh Chandra, Ruchi Tiwari, Ashish Srivastava, Gaurav Tiwari
Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-Agra-Delhi National Highway (NH-2), Bhauti, Kanpur, Uttar Pradesh, India


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Creative Commons License
© 2018 Mishra et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4. 0 International Public License (CC-BY 4. 0), a copy of which is available at: https://creativecommons. org/licenses/by/4. 0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this authors at the Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-Agra-Delhi National Highway (NH-2), Bhauti, Kanpur, Uttar Pradesh, India; E-mail: abhinavmph@gmail.com


Abstract

In designing of Prodrugs, targeting can be achieved in two ways: site-specified drug delivery and site-specific drug bioactivation. Prodrugs can be designed to target specific enzymes or carriers by considering enzyme-substrate specificity or carrier-substrate specificity in order to overcome various undesirable drug properties. There are certain techniques which are used for tumor targeting such as Antibody Directed Enzyme Prodrug Therapy [ADEPT] Gene-Directed Enzyme Prodrug Therapy [GDEPT], Virus Directed Enzyme Prodrug Therapy [VDEPT] and Gene Prodrug Activation Therapy [GPAT]. Our review focuses on the Prodrugs used in site-specific drug delivery system specially on tumor targeting.

Keywords: Prodrug, Xenobiotics, Cytotoxic, ADEPT, GDEPT, GPAT, VDEPT, NTR.