RESEARCH ARTICLE


Enumerating Antibiotic Susceptibility Patterns of Pseudomonas aeruginosa Isolated from Different Sources in Dhaka City



Mahmudullah Bhuiya1, Mohammad K. I. Sarkar2, Mehadi H. Sohag3, Hafij Ali2, *, Chapol K. Roy4, Lutfa Akther5, Abu F. Sarker6
1 Stamford University, Dhaka, Bangladesh
2 Independent University, Bangladesh (IUB), Bashundhara R/A, Dhaka-1212, Bangladesh
3 Jagannath University, Dhaka, Bangladesh
4 Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh
5 Dhaka Medical College Hospital, Bangladesh
6 Rajshahi University, Dhaka, Bangladesh


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Creative Commons License
© 2018 Bhuiya et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Independent University, Bangladesh (IUB), Bashundhara R/A, Dhaka-1212, Bangladesh; Tel: +88-02-8431991; E-mail: , hafij16@iub.edu.bd, hafij16@gmail.com


Abstract

Background:

Pseudomonas aeruginosa is a ubiquitous free-living bacterium and is responsible for severe nosocomial infections, life-threatening infections in immune compromised persons. The bacterium, along with its natural resistance, can acquire resistance to many antibiotics by a variety of methods.

Method:

Therefore, to compare the antibiotic sensitivity pattern of Pseudomonas aeruginosa, a total of seventeen isolates of P. aeruginosa were isolated from different sources; for example environmental sources, frozen food sources, clinical sources and medical waste materials. Isolates were confirmed to be P. aeruginosa by cultural and biochemical properties.

Result:

The isolates were tested against seventeen commercially available antibiotics to observe the antibiotic susceptibility patterns. Imipenem and meropenem were the most potent antibiotics (100% sensitivity) followed by amikacin and piperacillin with maximum sensitivity. Among others, gentamicin, ciprofloxacin, levofloxacin and aztreonam were found to be fairly active. A good number of isolates were intermediately resistant to ceftriaxone. The rates of resistance to aztreonam, cefotaxime and ceftazidime were 11.76%, 82.35% and 5.88% respectively. Complete resistance was observed against penicillin, ampicillin, cefixime and cefpodoxime.

Conclusion:

It can be concluded that the clinical isolates including isolate from medical waste, were multi-drug resistant than environmental and food isolates indicating the risk of transmission of resistance to the environmental isolates of P. aeruginosa.

Keywords: Pseudomonas aeruginosa, Different sources, Antibiotic susceptibility, Resistant, Environmental isolates, Gram-negative bacteria.