REVIEW ARTICLE


The Human Immune System toward Staphylococcus aureus



Rasoul Mirzaei1, Reza Ranjbar2, *, Sajad Karampoor3, Rezvan Goodarzi1, Hamze Hasanvand4
1 Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
2 Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
3 Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
4 School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


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Creative Commons License
© 2020 Mirzaei et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Molecular Biology Research Center Research, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran E-mail: ranjbar@bmsu.ac.ir


Abstract

The immune system is responsible for protecting the host from pathogens, and it has evolved to deal with these pathogens. On the other hand, the co-evolution of pathogenic bacteria with hosts has led to the rise of an array of virulence genes that enable pathogen bacteria to evade or modulate the immune system. Staphylococcus aureus is a significant pathogen of humans that encodes several virulence factors that can modulate or evade from the innate and adaptive arm of the immune system. Overall, the immune reaction toward S. aureus contributes to stimulate innate and adaptive reactions. A profound understanding of the immune response to S. aureus infections will be critical for the development of vaccines and novel therapies. In this review, we summarized and discussed the novel information about the human immune system against S. aureus.

Keywords: Staphylococcus aureus, Innate immunity, Adaptive immunity, Pathogen, Immune system, Methicillin-resistant S. aureus.