The Integrated Web Portal for Escalation with Overdose Control (EWOC)
Haibin Wang*, Mourad Tighiouart, Shao-Chi Huang, Dror Berel, Galen Cook-Wiens, Catherine Bresee, Quanlin Li , André Rogatko
Biostatistics & Bioinformatics Research Center, Cedars-Sinai Medical Center, 116 N. Robertson Blvd, Los Angeles, CA 90048, USA
Abstract
In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.
Keywords: EWOC, Bayesian method, cancer phase I clinical trial, maximum tolerated dose, open source.
Article Information
Article History:
Received Date: 2/1/2013
Revision Received Date: 15/4/2013
Acceptance Date: 20/4/2013
Electronic publication date: 31/5/2013
Collection year: 2013
© Wang et al.; Licensee Bentham Open.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (
http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to this author at the Biostatistics & Bioinformatics Research Center, Cedars-Sinai Medical Centre, 116 N. Robertson Blvd, Los Angeles, CA 90048, USA; Tel: 310-423-3315; Fax: 310-423-3315;
E-mail: Haibin.wang@cshs.org
Open Peer Review Details |
Manuscript submitted on 2-1-2013 |
Original Manuscript |
The Integrated Web Portal for Escalation with Overdose Control (EWOC) |