Synaptic Signals from Glutamate-Treated Neurons Induce Aberrant Post-Synaptic Signals in Untreated Neuronal Networks

Guaraldi, Mary; Lee, Sangmook; Shea, Thomas B.

Synaptic Signals from Glutamate-Treated Neurons Induce Aberrant Post-Synaptic Signals in Untreated Neuronal Networks

Mary Guaraldi¹, Sangmook Lee^{1, 2}, Thomas B. Shea^{1, *}^iD

¹ Laboratory for Neuroscience, Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA

² MassBiologics, Fall River, MA 02720, USA

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 14
First Page: 59
Last Page: 62
Publisher ID: TONEUJ-14-59
DOI: 10.2174/1874205X02014010059

Article History:

Received Date: 22/3/2020
Revision Received Date: 15/6/2020
Acceptance Date: 16/6/2020
Electronic publication date: 24/08/2020
Collection year: 2020

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© 2020 Guaraldi et al.

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^* Address correspondence to this author at the Laboratory for Neuroscience, Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA; Tel: 978-934-2881; Fax: 978-934-3044; E-mail: thomas_shea@uml.edu

Background and Objective:

Glutamate neurotoxicity is associated with a wide range of disorders and can impair synaptic function. Failure to clear extracellular glutamate fosters additional cycles and spread of regional hyperexcitation.

Methods and Results:

Using cultured murine cortical neurons, herein it is demonstrated that synaptic signals generated by cultures undergoing glutamate-induced hyperactivity can invoke similar effects in other cultures not exposed to elevated glutamate.

Conclusion:

Since sequential synaptic connectivity can encompass extensive cortical regions, this study presents a potential additional contributor to the spread of damage resulting from glutamate excitotoxicity and should be considered in attempts to mitigate neurodegeneration.

Keywords: Glutamate, Hyperactivity, Neurotoxicity, Multi-electrode arrays, Neurodegeneration, Synaptic signaling.

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RESEARCH ARTICLE

Synaptic Signals from Glutamate-Treated Neurons Induce Aberrant Post-Synaptic Signals in Untreated Neuronal Networks

Article Information

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Article History:

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Abstract

Background and Objective:

Methods and Results:

Conclusion:

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