Quan Liu1, Fang Xie2, Abdiel Alvarado-Diaz3, Mark A Smith4, Paula I Moreira5, Xiongwei Zhu4, George Perry*, 6
1 School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
2 Department of Neuroscience, School of Medicine, UCSD, La Jolla, CA, USA
3 Department of Biological Sciences, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico
4 Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
5 Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
6 College of Sciences, University of Texas at San Antonio, San Antonio, TX, USA
Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration. In this review, the most recent discovery and central arguments about functions, pathological modifications, and genetic mutations related to neurofilaments in neurodegenerative diseases is presented.
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* Address correspondence to this author at the University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249, USA; Tel: 210-458-4450; Fax: 210-458-4445; E-mail: email@example.com