Vincenzo Pizza1, Anella Agresta1, Antonio Agresta1, Eros Lamaida1, Norman Lamaida1, Francesco Infante2, Anna Capasso3, *
1 Neurophysiopathology Service, S. Luca Hospital, Vallo della Lucania (SA), Italy
2 Biochemical Laboratory, S. Luca Hospital, Vallo della Lucania (SA), Italy
3 Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Italy
The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated
In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine.
The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine.
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* Address correspondence to this author at the Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Italy; Tel: +39 089 969744; Fax: +39 089 966262; E-mail: email@example.com