Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?
Ari Pelcovits, Rachel Marriotti, Jonathan Heath, George Perry , Rudy J Castellani*
Division of Neuropathology, 22 South Greene Street, Baltimore, MD 21201
Environmental factors can play a role in the pathogenesis of Alzheimer’s disease. We present a case of the simultaneous onset of Alzheimer’s disease in two middle aged adults.
A married couple ages 54 year and 51-year-old female cohabiting together were diagnosed with Alzheimer’s disease within the same year. The patient’s both developed cognitive decline shortly after a major renovation of their property and followed a similar disease course. The diagnosis was supported by clinical presentation and tissue pathology on autopsy.
Environmental factors may play a role in the pathogenesis of Alzheimer’s disease. Further understanding of the disease cascade is required.
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* Address correspondence to this author at the Division of Neuropathology, 22 South Greene Street, Baltimore, MD 21201; Tel: 410-328-5508;
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