REVIEW ARTICLE
Ocular Signs Related to Overweight and Arterial Hypertension in Children: A Systematic Review
Daniela S. Schuh, Ângela B. Piccoli, Raquel L. Paiani, Cristiane R Maciel, Lucia C Pellanda, Manuel AP Vilela*
Article Information
Identifiers and Pagination:
Year: 2017Volume: 11
First Page: 273
Last Page: 285
Publisher ID: TOOPHTJ-11-273
DOI: 10.2174/1874364101711010273
Article History:
Received Date: 10/04/2017Revision Received Date: 20/05/2017
Acceptance Date: 18/06/2017
Electronic publication date: 31/08/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background:
The ocular effects of obesity and hypertension need to be established and can be used as prognostic markers.
Objective:
To estimate the prevalence of ophthalmological alterations in children and adolescents who are overweight and/or have SAH.
Methods:
The database for this study included all observational studies (CS, cohort, case-control and “baseline” description of randomized clinical trials) with children and/or adolescents who were overweight, obese or had SAH and that measured ophthalmological alterations.
Results:
Comparative studies with healthy children demonstrated positive association between body adiposity with retinal venular dilation, and SAH with retinal arteriolar narrowing. Different retinal fundus cameras and computer-assisted programs to evaluate the retinal vessels, variations in the methods of analysis, adjustments, populations, were the main arguments against formal meta-analysis. The heterogeneity was too high (I2 >90%, in fixed or randomized effects), and the lack of linearity, normal distribution and homoscedasticity did not recommend meta-regression.
Conclusion:
Obesity and SAH show associations with ophthalmological alterations, especially with retinal vessel diameter. Lack of standardization does not allow a quantitative evaluation.
