The Open Ophthalmology Journal

ISSN: 1874-3641 ― Volume 14, 2020

Outcomes of Wavefront-Optimized Laser-Assisted In-Situ Keratomileusis and Photorefractive Keratectomy for correction of Myopia and Myopic Astigmatism over One Year Follow-Up

Mohammad M. Shehadeh*, 1, 2, Mohammad T. Akkawi1, Ammar A. Aghbar1, Muna T. Musmar1, Malak N Khabbas1, Marah F Kharouf1, Liana Al-Labadi1
1 Faculty of Medicine and Health Sciences, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine
2 Vardinoyannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete, Greece



Laser corneal refractive surgery suits, technology and nomograms are improving with time. This may improve the refractive and visual outcomes of the patients.


To evaluate the safety, efficacy, stability, and predictability of wavefront-optimized photorefractive keratectomy and Laser-assisted in-situ keratomileusis in patients with myopia and myopic astigmatism over 1-year using WaveLight® EX500 Excimer Laser machine.


In this prospective cohort study, refractive and visual outcomes in 596 eyes (365 patients), either having myopia or myopic astigmatism were assessed. Patients were divided into Two groups: 1) Patients who underwent PRK (53 eyes have myopia and 217 eyes have myopic astigmatism), 2) Patients who underwent LASIK (53 eyes have myopia and 273 eyes have myopic astigmatism).


At 12 months postoperatively 94.3% of the myopic patients reached their preoperative best corrected distance visual acuity at the final one year follow up visit post PRK and LASIK. In patients with myopic astigmatism who underwent LASIK and PRK, 95.2%, and 96.3% of the patients reached their preoperative best corrected distance visual acuity at the final one year follow up visit post LASIK and PRK, respectively. The efficacy and safety indices were 1.00 or more for all groups with no eye lost any line of best corrected distance visual acuity.


Our study results confirm the excellent efficacy, safety, good predictability and stability of myopia / myopic astigmatism correction by either wavefront- optimized LASIK or PRK over 1-year follow-up without significant differences between them using the WaveLight® EX500 excimer laser system.

Keywords: Laser-assisted in-situ keratomileusis, Photorefractive keratectomy, Wavefront-optimized, Outcomes, Safety, Efficacy, Predictability.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 256
Last Page: 263
Publisher Id: TOOPHTJ-12-256
DOI: 10.2174/1874364101812010256

Article History:

Received Date: 19/1/2018
Revision Received Date: 24/7/2018
Acceptance Date: 30/8/2018
Electronic publication date: 26/09/2018
Collection year: 2018

© 2018 Shehadeh et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Ophthalmology Department, An-Najah National University Hospital, An-Najah National University, Nablus- West Bank- Palestine, Tel: +970 9 2343514; Fax: +970 9 2389684, E-mail:

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