The Open Orthopaedics Journal

ISSN: 1874-3250 ― Volume 14, 2020

Patients with Osteoarthritis in all Three Knee Compartments and Patients with Medial Knee Osteoarthritis Have a Phenotype with High Bone Mass and High Fat Mass but Proportionally Low Lean Mass

Magnus K Karlsson*, Håkan Magnusson, Thord von Schewelov, Maria Cöster, Caroline Karlsson , Björn. E Rosengren
Department of Orthopedics, Skåne University Hospital, SE-205 02 Malmö, Sweden


Background and Purpose:

Cross-sectional studies have shown that patients with primary hip osteoarthritis (OA) have higher bone mineral density (BMD), higher BMI, lower lean body mass, and higher fat content. But it is unknown if this phenotype is found also in patients with knee OA and if it precedes OA or manifests as a result of the disease.

Patients and Methods:

We included 21 women and 18 men (mean age, 71 years; range, 48-85 years) with primary OA in all three knee compartments, 17 women and 56 men (mean age, 55 years; range, 34-74 years) with primary medial knee OA and 122 women and 121 men without OA as controls. We measured total body BMD (g/cm2), fat and lean mass (%) by dual energy X-ray absorptiometry and also registered height and weight to calculate BMI (kg/m2). Z-scores were calculated for each individual. Data are presented as means with 95% confidence intervals within brackets.


Individuals with primary OA in all three knee compartments had the following Z-scores: total body BMD 0.4 (0.0, 0.9); BMI 1.2 (0.7, 1.6); proportion of lean mass -0.6 (-1.1, -0.1); proportion of fat mass 0.4 (0.0, 1.8). Individuals with medial knee OA had the following Z-scores: total body BMD 0.4 (0.3, 0.6); BMI 1.1 (0.8, 1.4); proportion of lean mass -0.8 (-1.3, -0.9); proportion of fat mass 0.9 (0.7, 1.1).


A phenotype with higher BMD, higher BMI, higher fat mass, and proportionally lower lean body mass is evident in individuals with primary OA in all three knee compartments and in patients with only medial knee OA.

Keywords: Generalized, knee, localized, men, osteoarthritis, women..

Article Information

Identifiers and Pagination:

Year: 2014
Volume: 8
First Page: 390
Last Page: 396
Publisher Id: TOORTHJ-8-390
DOI: 10.2174/1874325001408010390

Article History:

Received Date: 30/6/2014
Revision Received Date: 17/9/2014
Acceptance Date: 21/9/2014
Electronic publication date: 31 /10/2014
Collection year: 2014

© Karlsson et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Department of Orthopedics, Skåne University Hospital, SE-205 02 Malmö, Sweden; Tel: +4640331000; Fax +4640336200; E-mail:

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