Non-invasive transdermal focused ultrasound is an alternative method for body contouring, that is gaining interest both in patients and physicians. We report on a controlled clinical study assessing the safety and efficacy of a new therapeutic ultrasound device for non-invasive body contouring, named Proslimelt (PromoItalia Group S.p.A, Pozzuoli, Italy). A prospective study was conducted on 50 healthy patients (37 females and 13 males). The evaluation period lasted 8 consecutive weeks at the frequency of 1 session every 15 days for a mean total of 3,73 sessions. Results were assessed immediately after completion of the treatment protocol. Areas treated were the abdomen, the ankles, the arms, the buttocks and inner and outer thighs. Efficacy was determined by subjective and objective (plicometric and perimetric measurements, photographic and ultrasound evaluations) determinations. Safety was determined by clinical findings, assays of serum triglycerides, and hepatic transaminases. Finally, histopathological analyses were conducted in order to define morphological effects of the treatment. All patients showed significant reduction in subcutaneous fat thickness within the treated area, determined both by subjective an objective evaluations. Interestingly, weight was unchanged during the treatment and follow-up period and no adverse effects were observed. Histopathological analysis of the treated areas, showed cytoplasmic alteration of adipocytes. In conclusion the Proslimet device provides a safe and effective noninvasive technology for body contouring.
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