1 Department of Medicine, Health Sciences, University of Calgary, Calgary, Alberta, Canada
2 Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
Determine risk factors for infection following hip or knee total joint arthroplasty in patients with
All rheumatoid arthritis patients with a hip or knee arthroplasty between years 2000 and 2010 were identified
from population-based administrative data from the Calgary Zone of Alberta Health Services. Clinical data from patient
charts during the hospital admission and during a one year follow-up period were extracted to identify incident infections.
We identified 381 eligible procedures performed in 259 patients (72.2% female, mean age 63.3 years, mean body
mass index 27.6 kg/m2). Patient comorbidities were hypertension (43.2%), diabetes (10.4%), coronary artery disease
(13.9%), smoking (10.8%) and obesity (32%). Few infectious complications occurred: surgical site infections occurred
within the first year after 5 procedures (2 joint space infections, 3 deep incisional infections). Infections of non-surgical
sites (urinary tract, skin or respiratory, n=4) complicated the hospital admission. The odds ratio for any post-arthroplasty
infection was increased in patients using prednisone doses exceeding 15 mg/day (OR 21.0, 95%CI 3.5-127.2, p=<0.001),
underweight patients (OR 6.0, 95%CI 1.2-30.9, p=0.033) and those with known coronary artery disease (OR 5.1, 95%CI
1.3-19.8, p=0.017). Types of disease-modifying therapy, age, sex, and other comorbidities were not associated with an
increased risk for infection.
Steroid doses over 15 mg/day, being underweight and having coronary artery disease were associated with
significant increases in the risk of post-arthroplasty infection in rheumatoid arthritis. Maximal tapering of prednisone and
comorbidity risk reduction must be addressed in the peri-operative management strategy.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to this author at the 3330 Hospital Dr. NW,
Calgary, AB CANADA T2N 4N1, Canada; Tel: (403) 220-7725;
Fax: (403) 283-5666; E-mail: firstname.lastname@example.org