REVIEW ARTICLE


Novel and Controversial Therapies in COVID-19



Romil Singh1, Likhita Shaik2, Ishita Mehra3, 4, Rahul Kashyap5, Salim Surani6, *
1 Department of Medicine, Metropolitan Hospital, Jaipur, Rajasthan, India
2 Department of Oncology, Department of Medicine, Mayo Clinic, Rochester, MN, USA
3 Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA
4 Department of Internal Medicine, North Alabama Medical Center, Florence, AL, USA
5 Department of Anesthesiology and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA
6 Department of Pulmonary & Critical Care Medicine & Pharmacology, Texas A&M University, TX, USA


Article Metrics

CrossRef Citations:
21
Total Statistics:

Full-Text HTML Views: 2565
Abstract HTML Views: 888
PDF Downloads: 773
ePub Downloads: 370
Total Views/Downloads: 4596
Unique Statistics:

Full-Text HTML Views: 1043
Abstract HTML Views: 438
PDF Downloads: 540
ePub Downloads: 219
Total Views/Downloads: 2240



Creative Commons License
© 2020 Singh et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Department of Pulmonary & Critical Care Medicine & Pharmacology, Texas A&M University, TX, USA; E-mail: srsurani@hotmail.com


Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease (COVID-19) pandemic, which has led scientists all over the world to push for the identification of novel therapies for COVID-19. The lack of a vaccine and specific treatment has led to a surge of novel therapies and their publicity in recent times. Under these unprecedented circumstances, a myriad of drugs used for other diseases is being evaluated and repositioned to treat COVID-19 (example- Remdesivir, Baricitinib). While multiple trials for potential drugs and vaccines are ongoing, and there are many unproven remedies with little or no supporting evidence. Presently, discussions are revolving around the use of multivitamins (Vitamin, C, D, A), minerals (selenium, zinc), probiotics, flavonoids, polyphenols, and herbal remedies (curcumin, artemisinin, herbal drinks). Our review delves further into the details of some of these controversial therapies for COVID-19.

Keywords: COVID-19, Novel therapy, Antioxidant, Controversial therapy, Review, Pneumonia.