Not All Children with Under-Control Asthma are Controlled
G Ricci*, A Dondi, E Calamelli, V Dell’Omo, L Pagliara, T Belotti , M Masi
Department of Paediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
Subclinical lung function alterations can sometimes be discovered in asthmatic patients under clinical control. This study aimed to identify the burden of asthmatic children with subclinical airways abnormalities who may benefit from an adjustment in asthma therapy. 134 6-to-17-year-old asthmatic children were enrolled. Of them, 98 presented apparently under clinical control disease and all performed spirometry before and after bronchodilation: 17 (17.3%) had a positive bronchodilation test, in addition to significantly lower lung function indexes as compared to those with under-control asthma who had a negative bronchodilation test. These patients were randomized and re-evaluated: patients (n=8) receiving an adjustment in their therapy showed an improvement in lung function tests and quality of life indexes as compared to 7 without therapy adjustment. In conclusion, a substantial number of apparently-under-control asthmatic children show airways alterations that can be improved by adjusting their therapy, which also seems to enhance their quality of life.
Received Date: 10/1/2008 Revision Received Date: 16/1/2008 Acceptance Date: 23/1/2008 Electronic publication date: 6/2/2008 Collection year: 2008
2008 Bentham Science Publishers Ltd
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
* Address correspondence to this author at the Department of Paediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; E-mail: firstname.lastname@example.org