1 Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Research Center of Chemical Injuries, Baqiyatallah University of Medical Sciences, Tehran, Iran
Gastroesophageal reflux disease (GERD) is widely associated with asthma, chronic cough, and laryngitis.
Many studies have focused on acidic reflux; however, acid is just one of many factors that can cause pulmonary injury.
The discrepancy between the high frequency of GERD in asthmatic patients and the ineffective reflux therapy outcomes
in these patients suggests that GERD may cause injury through other mechanisms, such as pepsinogen, pepsin, bile salts,
or other components of reflux materials, instead of the acid. Research using appropriate and innovative methodologies to
investigate these potential inflammatory agents in patients with GERD is required to determine the underlying factors
associated with pulmonary disorders in these patients.
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* Address correspondence to this author at the Baqiyatallah University of Medical, Sciences, Research Center of Chemical Injuries, P.O. Box: 19945-546, Tehran, Iran; Tel: +98 21 88600067; Fax: +98 21 88211524; E-mail: email@example.com