Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer
Huang Yan1, Lin Guoqiang2, Chen Shengxi2, Deng Zhenghao3, Huang Lingjin*, 2
1 Department of Infectious Disease, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China
2 Department of Cardiothoracic Sugery, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China
3 Department of Pathology, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China
Raf kinase inhibitor protein (RKIP) had been identified as one of prognostic indictor in various malignant diseases. Association of RKIP expression and the clinical-pathological features were not investigated in patients with resectable non-small cell lung cancer (NSCLC).
Materials and Methodology:
159 sectioned samples from surgical NSCLC patients were investigated by immunohistochemistry in order to reveal the associations between RKIP expression and clinical-pathologic features.
Statistically, Lower RKIP expression level was found in the group with higher N stage (P<0.01) and higher TNM stage (P<0.05). No significant correlation was observed between RKIP expressions and histologic type (P>0.05) and tumor size (P>0.05).
Down expression level of RKIP was found relating to lymph node metastasis in resectable NSCLC patients in this study.
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* Address correspondence to this author at the Department of Cardiothoracic Sugery, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China; Tel: +8673184323003; E-mail: email@example.com