The Open Respiratory Medicine Journal

ISSN: 1874-3064 ― Volume 14, 2020

Biomarkers of Fibroproliferative Healing in Fibrosing Idiopathic Interstitial Pneumonias

Martina Vasakova*, 1, Martina Sterclova 1, Eliska Stranska 2, Petra Mandakova 2, Jelena Skibova 3, Radoslav Matej 4
1 Department of Respiratory Medicine, Thomayer Hospital, Videnska 800, 14059 Prague 4, Czech Republic
2 Department of Pathology and Molecular Medicine, Charles University in Prague, 2nd Medical Faculty, V Uvalu 84, 15006 Prague 5, Czech Republic
3 Medical Statistics Unit, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021 Prague 4, Czech Republic
4 Department of Pathology and Molecular Medicine, Thomayer Hospital, Videnska 800, 14059 Prague 4, Czech Republic



The main feature of fibrosing idiopathic interstitial pneumonias (fIIPs) is the fibroproliferative potential of underlying pathogenetic process. We hypothesize that the concentration of potential markers of fibroproliferative healing, PAR-2, TGF-β1, TNF-α and IL-4Rα in bronchoalveolar lavage fluid (BALF) differ in patients with fIIPs compared to controls (C).

Patients and Methods:

10 patients with fIIPs and 9 controls (C) were included to the study.

Concentrations of CD124 (IL4Rα), PAR-2, TGF-β1 and TNF-α in BALF were determined using the ELISA method.


We observed higher concentrations of IL4Rα (fIIPS 1499.4 pg/ml vs C 255.5 pg/ml; p < 0.05), PAR-2 (fIIPS 1807.9 pg/ml vs C 421.0 pg/ml; p < 0.05) and TGF-β1(fIIPS 283.0 pg/ml vs C 197.1 pg/ml; p < 0.01) in BALF in fIIPs versus C. The values of TNF-a in BALF did not differ significantly in fIIPs compared to controls. The ratios also showed differences in fIIPS and C: IL4Rα/TGF-β1 (fIIPS 6.19 vs C 0.68; p = 0.0143); TNF-α/IL4Rα (fIIPS 0.84 vs C 7.93; p = 0.043); TGF-β1/TNF-α (fIIPS 0.21 vs C 0.16; p = 0.0179) and protein/PAR-2 (fIIPS 0.06 vs C 0.28; p = 0.0033).


We found that PAR-2, TGF-β1 and IL-4Rα are significantly up-regulated in the BALF of fIIPs compared to controls, therefore we suppose they could become biomarkers of fibroproliferative healing.

Keywords: Idiopathic interstitial pneumonias, fibroproliferative healing, biomarkers, bronchoalveolar lavage fluid, PAR-2, TGF-beta, IL4R..

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 6
First Page: 160
Last Page: 164
Publisher Id: TORMJ-6-160
DOI: 10.2174/1874306401206010160

Article History:

Received Date: 10/10/2012
Revision Received Date: 11/11/2012
Acceptance Date: 21/11/2012
Electronic publication date: 28/12/2012
Collection year: 2012

© Vasakova et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Respiratory Medicine, Thomayer Hospital Prague, Videnska 800, 140 59 Prague 4, Czech Republic; Tel: + 42026108 2372; Fax: + 42026108 2206; E-mail:

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