TGF-β Made Easy

Garcia-Fernandez , N.; Molina, M.L. Marco

TGF-β Made Easy

N. Garcia-Fernandez , M.L. Marco Molina^*

Clínica Universitaria de Navarra, Departments of Nephrology and General Surgery, Pio XII 38, Pamplona 31008, Pamplona, Navarra, Spain

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Identifiers and Pagination:

Year: 2009
Volume: 2
First Page: 1
Last Page: 5
Publisher ID: TOUNJ-2-1
DOI: 10.2174/1874303X01002010001

Article History:

Received Date: 20/10/2008
Revision Received Date: 29/12/2008
Acceptance Date: 29/1/2009
Electronic publication date: 2/3/2009
Collection year: 2009

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2008 Bentham Science Publishers Ltd.

^* Address correspondence to this author at the Clínica Universitaria de Navarra, Departments of Nephrology and General Surgery, Pio XII 38, Pamplona 31008, Pamplona, Navarra, Spain; Tel: 0034 948255400; E-mail: mmarcomolina@gmail.com

Renal fibrosis is the final common pathway of several nephropathies including chronic allograft failure. Most chronic renal diseases result in tissue fibrosis, and this is independent of their initial cause. Tissue fibrosis is an accumulation of extracellular matrix, and in animal models of renal fibrosis, mRNA levels for profibrogenic cytokines such as transforming growth factor β (TGFβ) and extracellular matrix (ECM) molecular components are up regulated and they precede glomerulosclerosis and interstitial fibrosis. TGFβ 1 plays a crucial role in renal fibrosis. In this review the main features of this important cytokine and existing previous therapeutic attempts to inhibit TGFβ expression are briefly summarised.

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Hernandes F. de Carvalho
Institute of Biology
State University of Campinas
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The Open Urology & Nephrology Journal
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RESEARCH ARTICLE

TGF-β Made Easy

Article Information

Identifiers and Pagination:

Article History:

Article Metrics

CrossRef Citations:

Total Statistics:

Unique Statistics:

Abstract

Track Your Manuscript

Published Contents

About the Editor

About the Journal

The Open Urology & Nephrology Journal

Journal Metrics

Readership Statistics:

Total Views/Downloads: 1,848,967

Unique Views/Downloads: 362,319

Press Release

Bentham Open Welcomes Sultan Idris University of Education (UPSI) as Institutional Member

Ministry Of Health, Jordan joins Bentham Open as Institutional Member

Porto University joins Bentham Open as Institutional Member

Join Our Editorial Board

Testimonials