1994 - LOCI developed by Syva/Dade Behring to measure clinical analytes in human fluids [6,7] |
1999 - LOCI commercialized for nucleic acid detection in miniaturized formats [9] |
1999 - LOCI technology licensed by PerkinElmer for drug discovery applications [1] |
2001 - AlphaScreen HTS cAMP assay [10,11] |
2001 - AlphaScreen assay for single nucleotide polymorphism (SNP) detection [2, 20, 21] |
2002 - AlphaScreen Nuclear Receptor Assay 3, [16, 18] |
2003 - AlphaScreen Ins P3 assay [12] |
2003 - AlphaScreen Protease assay [8, 14] |
2003 - AlphaScreen protein kinase assays [11, 13] |
2005 - AlphaScreen Transcription factor assays [19] |
2005 - AlphaScreen Ubiquitin ligase assay [33] |
2006 - Cell based kinase assays using Surefire (AlphaScreen) technology [5] |
2006 - Homogeneous ELISA (AlphaLISA) assays [15, 37] |