Table 1: Comparison of disease symptoms and characteristics for Wolman Disease vs. Cholesteryl Ester Storage Disease.

Disease Symptoms/Characteristics	Wolman Disease	Cholesteryl Ester Storage Disease
Lipid Profile	Elevated LDL-cholesterol, triglycerides. Reduced levels of HDL	Elevated LDL-cholesterol, triglycerides, serum total cholesterol [16] Reduced levels of HDL
Liver Function	Elevated ALT + AST	Elevated ALT + AST
Hepatic Pathology	Yellow and greasy. Infiltration by lipid-filled Kupffer cells [30]. Fibrosis.	Microvesicular steatosis of the hepatocytes. Cirrhosis. Infiltration by lipid-filled Kupffer cells and macrophages [36]
Splenic Pathology	Enlarged spleen [27]	Enlarged spleen [11]
Adrenal Pathology	Calcification of the adrenal glands [25]	Very rare calcification of the adrenal glands [16]
Intestinal Pathology	Massive CE and TG accumulation in the small intestine. Infiltration of the lamina propria by foamy macrophages [34]	CE accumulation, but to a much lesser degree than WD [16]
Biochemical Features	No functioning levels of LAL [34]	1-12% of functioning LAL relative to healthy patients [11]
Age of Onset	First few months of birth [34]	Childhood to Adulthood [16]
Life Expectancy	<1 year [34]	Patients live into adulthood [16]
Causes of Death	Malnutrition, malabsorption, liver failure [34]	Liver failure [16]