Table 1.: Compound IC50 (µM) values by neuronal cell type and test mode.

    Antimycin A1 CCCP2 Nocodazole3 SAHA4 Staurosporine5
Cell type Test Mode (Compound Exposure Time) Neurite
Outgrowth
IC50 		Cell
Viability
IC50 		Neurite
Outgrowth
IC50 		Cell
Viability
IC50 		Neurite
Outgrowth
IC50 		Cell
Viability
IC50 		Neurite
Outgrowth
IC50 		Cell
Viability
IC50 		Neurite
Outgrowth
IC50 		Cell
Viability
IC50
Neuroscreen-1 (PC-12 subclone) Chronic
(3 days)		 - - - - 0.2 0.1 - - 0.09 0.04
Rat cortex neurons Chronic
(4 days)		 - - 3.9 3.3 0.4 0.3 ~3 ~7 0.004 0.005
iCell Neurons Acute
(1 hour)		 >300 >300 - - ~20 >30 - - 3.6 2.9
iCell Neurons Chronic
(10 days)		 28 25 - - 0.4 0.6 - - 0.4 0.1

1 Antimycin A is a mitochondrial oxidative phosphorylation inhibitor
2 CCCP (carbonyl cyanide m-chlorophenyl hydrazone) is a mitochondrial oxidative phosphorylation inhibitor
3 Nocodazole is a microtubule polymerization inhibitor, mitotic inhibitor
4 SAHA (suberoylanilide hydroxamic acid) is a histone deacetylase (HDAC) inhibitor
5 Staurosporine is a pan-kinase inhibitor