A Facile Synthesis of (Z)-2-((5-(4-fluorobenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl) amino) Substituted Acid Using Microwave Irradiation and Conventional Method

Table 2: Physical data for synthesized rhodanine derivatives 6(a-l)^a.

Sr. No.	Substituent (R)	Time (min)		Yield^b ( %)		Melting point (ºC)
Sr. No.	Substituent (R)	MW^c	Con^d	MW^c	Con^d	Melting point (ºC)
6a	-CH3	4	30	96	90	230-232
6b	-CH(CH3)2	4	40	96	80	202-204
6c	-CH(CH3)CH2CH3	3	35	94	82	140-142
6d	-CH2C6H5	3	45	93	80	170-172
6e	-CH2CH2SCH3	3	45	94	82	156-158
6f	-CH2CH(CH3)2	4	35	94	84	233-235
6g	-CH2OH	3	30	95	82	201-203
6h	-CH2SH	4	35	94	84	206-208
6i	-CH2COOH	4	50	96	80	182-184
6j		3	50	92	76	192-194
6k	-CH2C6H4OH	3	45	92	72	150-152
6l	-CHOHCH3	3	35	94	78	170-172

^a Reaction condition (6a-l). Compound (4) (1 mmol), amino acids (5a-l) (1.2 mmol),

Method A: Microwave-assisted synthesis: potassium carbonate, ethanol, 70 ºC, 3-4 min.

Method B: Conventional synthesis: potassium carbonate, ethanol room temperature, 30-50 min.

^b Isolated yields.

^c Microwave-assisted.

^d Conventional condition.