Synthesis, Characterization and Antifungal Assessment of Optically Active Bis-organotin Compounds Derived from (S)-BINOL Diesters

Table 4: Percentages of inhibition of organotin compounds against C. albicans ATCC 10231 (Ca) and C. neoformans ATCC 32264 (Cn).

Structure	Fungi	Concentrations (µg/mL)										MIC^a	IC₅₀^a
Structure	Fungi	250	125	62.5	31.2	15.6	7.8	3.9	2	1	0.5	MIC^a	IC₅₀^a
Percentages of Inhibition (%)
	Ca	3.5 ± 0.8	1.0 ± 0.7	0.7 ± 0.1	0.6 ± 0.0	0.4 ± 0.1	0	0	0	0	0	>250	>250
	Cn	0	0	0	0	0	0	0	0	0	0	>250	>250
	Ca	53.1 ± 0.0	28.9 ± 1.3	15.8 ± 0.1	5.9 ± 0.6	4.5 ± 0.0	2.7 ± 0.2	2.3 ±0.4	0	0	0	>250	250
	Cn	65.9 ± 0.8	46.6 ± 0.5	15.8 ± 1.9	15.0 ± 0.2	9.7 ± 0.1	0	0	0	0	0	>250	250
	Ca	70.2 ± 0.1	18.1 ± 1.5	1.73 ± 1.8	0.6 ± 0.9	0	0	0	0	0	0	>250	250
	Cn	39.5 ± 0.8	12.6 ± 0.2	11.5 ± 0.2	9.8 ± 0.2	6.6 ± 0.2	6.4 ± 0.8	5.9 ± 0.2	0	0	0	>250	>250
	Ca	100	100	100	100	100	100	100	97.1 ± 0.0	68.9 ± 0.2	21.9 ± 0.8	3.9	1
	Cn	100	100	100	100	100	100	100	100	68.4 ± 0.5	31.1 ± 0.5	2	1
	Ca	100	100	96.0 ± 1.1	33.0 ± 0.5	29.4 ± 0.1	5.1 ± 1.0	3.4 ± 0.4	0	0	0	125	62.5
	Cn	93.1 ± 0.8	66.3 ± 2.0	30.1 ± 0.3	18.3 ± 0.9	9.4 ± 1.3	8.5 ± 1.0	8.1 ± 1.7	0	0	0	>250	125
	Ca	100	100	100	100	100	100	100	32.4 ± 0.6	9.6 ± 0.1	0	3.9	3.9
	Cn	100	100	100	100	100	100	100	52.0 ± 1.6	35.7 ± 0.3	12.6 ± 1.0	3.9	1.9
	Ca	100	100	100	100	100	100	85.7 ± 0.1	51.4 ± 1.0	27.5 ± 0.6	3.8 ± 0.7	7.8	2
	Cn	100	100	100	100	65.4 ± 0.6	30.0 ± 0.3	11.5 ± 1.1	0	0	0	31.25	15.6
	Ca	100	100	93.2 ± 0.2	51.8 ± 1.7	10.5 ± 1.1	3.4 ± 0.1	0.7 ± 0.7	0	0	0	125	31.25
	Cn	100	100	97.4 ± 0.9	87.7 ± 0.2	49.3 ± 0.4	22.4 ± 2.2	7.8 ± 2.0	0	0	0	125	15.6
Amphotericin B	Ca Cn	100 100	100 100	100 100	100 100	100 100	100 100	100 100	100 100	100 100	100 100	1.5 1.5	0.5 0.25

^a in µg/mL.