Table 5: Antimicrobial activity of purified phthalates isolated from natural sources.

Antimicrobial Activity Phthalate Organism Source Part Extracted Reference
Staphylococcous aureus Bis(2-ethylhexylphthalate) (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
S. aureus Bis(2-ethylhexylphthalate) (9) Streptomyces mirabilis broth extract M. El-Sayed, 2012 [144]
S. aureus Bis(2-ethylhexylphthalate) (9) Streptomyces sp. TN17 broth extract S. Smaoui et al., 2011 [302]
S. aureus / MIC 32 μg/mL Bis(2-ethylhexyl) phthalate (9) Streptomyces bangladeshiensis M.A.A. Al-Bari et al., 2006 [303]
S. aureus 209P FDA /MIC >300 μg/mL Di-n-butyl phthalate (5) Streptomyces nasri H35 Broth extract M.Y. El-Naggar, 1997 [214]
S. aureus NRRL B 313 Bis(2-ethylhexylphthalate) (9) Streptomyces SB9 Broth extract D. Lyutskanova et al., 2009 [304]
S. aureus MTCC 96/ MIC 18.75 μg/mL Bis(2-ethylhexylphthalate) (9) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
S. aureus MTCC 96/ MIC 37.5 μg/mL Di-n-butyl phthalate (5) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
Staphylococcus epidermis MTC 435 /MIC 9.37 μg/mL Bis(2-ethylhexylphthalate) (9) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
Staphylococcus epidermis MTC 435 /MIC 9.37 μg/mL Bis(2-ethylhexylphthalate) (9) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
Acinetobacter johnsonii ATCC17909 Bis(2-ethylhexylphthalate) (9) Streptomyces SB9 Broth extract D. Lyutskanova et al., 2009 [304]
Aeromonas hydrophila 2 μg/mL Bis(2-ethylhexylphthalate) (9 Streptomyces ruber EKH2 K.M. Barakat and E.A. Beltagy, 2015 [305]
Bacillus mycoides DSMZ274 (resistant) Bis(2-ethylhexylphthalate) (9) Streptomyces SB9 Broth extract D. Lyutskanova et al., 2009 [304]
Bacillus subtilis MIC 32 μg/mL Bis(2-ethylhexylphthalate) (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
B. subtilis Bis(2-ethylhexylphthalate) (9) Vicia villosa shoots M.T. Islam et al., 2013 [181]
B. subtilis Bis(2-ethylhexylphthalate) (9) Streptomyces mirabilis broth extract M. El-Sayed, 2012 [144]
B. subtilis Diethyl phthalate (7) Vicia villosa shoots M.T. Islam et al., 2013 [181]
B. subtilis MTCC 441 /MIC 37.5 μg/mL Bis(2-ethylhexylphthalate) (9) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
B. subtilis MTCC 441 /MIC 18.75 μg/mL Di-n-butyl phthalate (5) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
B. subtilis 6633 ATCC /MIC >400 μg/mL Di-n-butyl phthalate (5) Streptomyces nasri H35 Broth extract M.Y. El-Naggar, 1997 [214]
B. subtilis 6633 Bis(2-ethylhexylphthalate) (9) Streptomyces SB9 Broth extract D. Lyutskanova et al., 2009 [304]
B. subtilis 6633 / MIC 84 μg/mL Di-n-butyl phthalate (5) Streptomyces albidoflavus N. Roy et al., 2006 [217]
B. subtilis / MIC 16 μg/mL Bis(2-ethylhexyl) phthalate (9) Streptomyces bangladeshiensis M.A.A. Al-Bari et al., 2006 [303]
Bacillus cereus PX MU-COB / MIC >300 μg/mL Di-n-butyl phthalate (5) Streptomyces nasri H35 Broth extract M.Y. El-Naggar, 1997 [214]
Bacillus megatherium (resistant) Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
Bacillus megatherium NRRL 1353895 Bis(2-ethylhexyl) phthalate (9) Streptomyces SB9 Broth extract D. Lyutskanova et al., 2009 [304]
Closteridium perfringens Bis(2-ethylhexyl) phthalate (9) Streptomyces mirabilis broth extract M. El-Sayed, 2012 [144]
Salmonella typhi 653 / MIC 76 μg/mL Di-n-butyl phthalate (5) Streptomyces albidoflavus N. Roy et al., 2006 [217]
S. typhi / MIC 16 μg/mL Bis(2-ethylhexyl) phthalate (9) Streptomyces bangladeshiensis M.A.A. Al-Bari et al., 2006 [303]
Sarcina lutea / MIC 32 μg/mL Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
Sarcina lutea ATCC9341 Bis(2-ethylhexyl) phthalate (9) Streptomyces SB9 Broth extract D. Lyutskanova et al., 2009 [304]
Edwardsiella tarda 8 μg/mL Bis(2-ethylhexyl) phthalate (9) Streptomyces ruber EKH2 K.M. Barakat and E.A. Beltagy, 2015 [305]
Escherchia coli Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
E. coli Bis(2-ethylhexyl) phthalate (9) Streptomyces mirabilis broth extract M. El-Sayed, 2012 [144]
E. coli ATCC 8739 (resistant) Bis(2-ethylhexyl) phthalate (9) Streptomyces sp. TN17 broth extract S. Smaoui et al., 2011 [302]
E. coli MTCC 443 / MIC 37.5 μg/mL Bis(2-ethylhexyl) phthalate (9) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
E. coli MTCC 443 / MIC 37.5 μg/mL Di-n-butyl phthalate (5) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
E. coli 25922 / MIC 53 μg/mL Di-n-butyl phthalate (5) Streptomyces albidoflavus broth extract N. Roy et al., 2006
Klebsiella pneumoniae
(MTCC 618) / MIC 75 μg/mL
Bis(2-ethylhexyl) phthalate (9) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
Klebsiella pneumoniae
(MTCC 618) / MIC 75 μg/mL
Di-n-butyl phthalate (5) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
Micrococcus luteus Bis(2-ethylhexyl) phthalate (9) Streptomyces sp. TN17 broth extract S. Smaoui et al., 2011 [302]
Pseudomonas aeruginosa Bis(2-ethylhexyl) phthalate (9) Streptomyces mirabilis broth extract M. El-Sayed, 2012 [144]
P. aeruginosa MTCC 741 / MIC 75 μg/mL Bis(2-ethylhexyl) phthalate (9) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
P. aeruginosa MTCC 741 / MIC 37.5 μg/mL Di-n-butyl phthalate (5) Brevibacterium McBellneri M. Rajamanikyam et al., 2017 [164]
P. aeruginosa 8 μg/mL Bis(2-ethylhexylphthalate) (9 Streptomyces ruber EKH2 broth extract K.M. Barakat and E.A. Beltagy, 2015 [305]
Pseudomonas fluores-cens / MIC >300 μg/mL Di-n-butyl phthalate (5) Streptomyces nasri H35 broth extract M.Y. El-Naggar, 1997 [214]
Shigella sonnei Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
Shigella shiga Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
Shigella dysenteriae Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
S. dysenteriae / MIC 32 μg/mL Bis(2-ethylhexyl) phthalate (9) Streptomyces bangladeshiensis M.A.A. Al-Bari et al., 2006 [303]
Rhizobium vitis Bis(2-ethylhexyl) phthalate (9) Vicia villosa shoots M.T. Islam et al., 2013 [181]
R. vitis Diethyl phthalate (7) Vicia villosa shoots M.T. Islam et al., 2013 [181]
Streptococcus equosemens Bis(2-ethylhexyl) phthalate (9) Streptomyces mirabilis broth extract M. El-Sayed, 2012 [144]
Vibrio ordalii Bis(2-ethylhexylphthalate) (9 Streptomyces ruber EKH2 broth extract K.M. Barakat and E.A. Beltagy, 2015 [305]
Aspergillus flavus Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
A. flavus (rel. resistant) Bis(2-ethylhexyl) phthalate (9) Streptomyces mirabilis broth extract M. El-Sayed, 2012 [144]
A. flavus / MIC 128 μg/mL Bis(2-ethylhexyl) phthalate (9) Streptomyces bangladeshiensis broth extract M.A.A. Al-Bari et al., 2006 [303]
Aspergillus fumigatus
(resistant)
Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea
Streptomyces mirabilis
flower
broth extract
M.R. Habib and M.R. Karim, 2009 [143]
M. El-Sayed, 2012 [144]
A. fumigatus Di-n-butyl phthalate (5) Streptomyces nasri H35 Broth extract M.Y. El-Naggar, 1997 [214]
Aspergillus niger
(resistant)
Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea
Streptomyces mirabilis
flower
broth extract
M.R. Habib and M.R. Karim, 2009 [143]
M. El-Sayed, 2012 [144]
A. niger 1781 / MIC 98 μg/mL Di-n-butyl phthalate (5) Streptomyces albidoflavus broth extract N. Roy et al., 2006 [217]
A. niger / MIC 64 μg/mL Bis(2-ethylhexyl) phthalate (9) Streptomyces bangladeshiensis broth extract M.A.A. Al-Bari et al., 2006 [303]
Curvularia pallescens 403 / 117 μg/mL Di-n-butyl phthalate (5) Streptomyces albidoflavus broth extract N. Roy et al., 2006 [217]
Fusarium sp. Bis(2-ethylhexyl) phthalate (9) Streptomyces sp. TN17 broth extract S. Smaoui et al., 2011 [302]
Fusarium sp.
(resistant)
Bis(2-ethylhexyl) phthalate (9) Calotropis gigantea flower M.R. Habib and M.R. Karim, 2009 [143]
Trichosporon cutaneum R57 Bis(2-ethylhexyl) phthalate (9) Streptomyces SB9 broth extract D. Lyutskanova et al., 2009 [304]
Candida albicans Bis(2-ethylhexyl) phthalate (9) Streptomyces mirabilis broth extract M. El-Sayed, 2012 [144]
C. albicans / MIC 64 μg/mL Bis(2-ethylhexyl) phthalate (9) Streptomyces bangladeshiensis broth extract M.A.A. Al-Bari et al., 2006 [303]
Candida tropicalis ATCC20336 Bis(2-ethylhexyl) phthalate (9) Streptomyces SB9 broth extract D. Lyutskanova et al., 2009 [304]
Saccharomyces cerevisiae (resistant) Di-n-butyl phthalate (5) Streptomyces nasri H35 broth extract M.Y. El-Naggar, 1997 [214]
S. cerevisiae DSM70449 Bis(2-ethylhexyl) phthalate (9) Streptomyces SB9 broth extract D. Lyutskanova et al., 2009 [304]
S. cerevisiae 176 / MIC 92 μg/mL Di-n-butyl phthalate (5) Streptomyces albidoflavus broth extract N. Roy et al., 2006 [217]