| - | Case 1 – CNS Toxoplasmosis | Case 2 – Disseminated MAC | Case 3 – TB Lymphadenitis | Case 4 – Microsporidiosis |
|---|---|---|---|---|
| Demographics Age (years) Gender |
49 M |
23 M |
56 M |
45 M |
| HIV/AIDS information CD4+ cell count (cells/μL) HIV-1 viral load (copies/mL) |
4 197,000 |
9 809,000 |
25 527,000 |
339 221,000 |
| Localization of infection | CNS | Disseminated | Disseminated | Gastrointestinal |
| Other microbiology tests ordered | - Blood cultures for bacteria, fungi, AFB - Blood TB T-spot - Blood antigen for Strongyloides, Cryptococcus, Histoplasma and Toxoplasma - BAL cultures for bacteria, fungi, AFB, Mycoplasma and Legionella; PCR for Chlamydia pneumoniae - CSF cultures, PCR for Toxoplasma, JC virus, EBV, TB - Brain tissue pathology staining for multiple organisms |
- Blood cultures for bacteria, fungi, AFB - Bone marrow biopsy cultures and staining for bacteria, viruses, fungi, AFB |
- Blood cultures for bacteria, fungi, AFB - BAL cultures for bacteria, viruses, fungi, AFB, Mycoplasma and Legionella; PCR for Chlamydia pneumoniae - Lung tissue cultures and staining for bacteria, viruses, fungi, AFB - CSF cultures, VDRL and antigens for Cryptococcus and WNV - Lymph node biopsy tissue cultures and staining for bacteria, fungi, AFB |
- CSF cultures, multiple viral PCRs, and AFB stain/culture - Stool ova and parasites - GI pathogen PCR panel |
| Positive microbiology test(s) | Blood Toxoplasma IgG; CSF Toxoplasma PCR; Brain tissue Toxoplasma stain | Bone marrow biopsy AFB culture; AFB blood culture | Lung tissue AFB culture; lymph node tissue x2 AFB stain and culture | GI pathogen panel positive Norovirus and Cryptosporidium |
| NGS result(s) | Toxoplasma gondii; Cytomegalovirus; Nocardia farcinica; Enterococcus faecalis and Enterococcus faecium | Mycobacterium avium complex | Mycobacterium tuberculosis; EBV | Enterocytozoon bieneusi |