Fig. (2) Biomarker levels (median, IQR; n = 17) on the lesional (L) and non-lesional skin (2 cm and 4 cm distance from the lesion) determined in tape no. 8 (T8). The difference in biomarker levels between lesional and non-lesional skin sites was tested by repeated-measures ANOVA followed by linear trend analysis. The differences between non-lesional skin sites at 2 cm and 4 cm were tested by two-sided paired t-test or Wilcoxon matched-pairs signed rank test. P-value < 0.05 was considered significant. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.