| Inductors | Response | Molecules Implicated | References |
|---|---|---|---|
| Glucose withdrawal | Apoptosis | Bax, Bcl-2, Bcl-xl, Mcl-1 | Vander Heiden et al. [11], Lee et al. [12],
Gonin-Giraud et al. [13], Alves et al.[28]. |
| Caspase-8 | Caro-Maldonado et al. [33] | ||
| Bad, PUMA, Bim, Noxa, p53 | Danial et al. [17], Zhao et al.[21],
Alves et al. [28]. |
||
| Necrotic phenotype | Yuneva et al. [15], Suzuki et al. [37] | ||
| Survival | AMPK, mTOR, p53 | Jones et al. [4], Liang et al. [5], Wang et al. [6] | |
| Ischemia, ischemic-like in vitro conditions | Necrosis, apoptosis | AKT, ROS, Bax, Bak | Degenhardt et al. [32], Bahi et al. [34].
For reviews, see Lee et al. [47], Broughton et al. [35] |
| Glutamine withdrawal | Apoptosis | Myc, Bcl-2, caspase-9 | Yuneva et al. [15], Julie et al. [16] |