| Expt No. | Moles of MsCl | Process Set Point | TEA Moles eq | HPLC Results | Comments |
|---|---|---|---|---|---|
| Expt No. 5 | 1.3 | 2.2 to 2.35 mole equivalents of TEA. | 1.5 | 93.89% Mesylate, 5.81 % UK Yield: 87.40% |
TEA qty should not be less than optimised qty. |
| Expt No. 6 | 1.3 | 3.0 | 99.18% Mesylate, 0.81 % carbinol Yield: 93.33% |
No adverse effect on quality of mesylate when excess of TEA was used | |
| Expt No. 7 | 1.3 | 2.1 | 94.66% Mesylate, 4.85 % UK |
Yield: 93.33% | |
| Expt No. 8 | 1.3 | 2.3 | 99.22% Mesylate, 0.77% carbinol |
Yield: 90.37% |