| Study (Year) | Location | Design | Study Population | N | Confounders Assessed | Age | BMI | Clinical Outcomes |
|---|---|---|---|---|---|---|---|---|
| Dursun 2011 |
Turkey | Case-control study | Non obese never smoker women with normal glucose tolerance and without history of systemic disease or any drug use (oral contraceptives for ≥ 3 months) S: PCOS diagnosed with Rotterdam Criteria (n=25) C: Age and weight matched systemically healthy women with regular menstrual cycles without clinical or biochemical hyperandrogenism or PCOS (n=27) |
52 | Cushing's syndrome, congenital adrenal hyperplasia, hyperprolactinemia, thyroid disorders, androgen secreting tumors, smoking, oral contraceptives use ≥3 months. BMI | S: 22.7±3.6 C: 24.2±2.5 |
S:22.4±2.50 C: 20.6±1.9 |
CAL,PD,GI,%BOP,PI |
| Porwal 2014 |
India | Case-control study | Reproductive age women diagnosed with >16 natural teeth. S: PCOS diagnosed with Rotterdam Criteria (nN=41, nM=45) C: systemically healthy age matched regularly menstruating women with no clinical or biochemical sign of hyperandrogenism and ultrasound exclusion of PCOS (n=40) |
126 | Thyroid disorders, hyperprolactinemia, androgen-secreting tumors, chronic inflammatory diseases (nephrotic syndrome, chronic renal failure, significant cardiovascular disease, established type 1 or type 2 diabetes mellitus, or active cancer within the past 5 years), smoking, alcoholism, antibiotics within 3 months, periodontal treatment within 6 months, aggressive periodontitis and BMI | N:23.09±4.90M:22.68±4.55 C:23.50±2.67 |
N: 25.01±3.61 M: 24.57±4.38 C: 23.76±4.82 |
CAL,PD,GI,%BOP,PI |
| Rahiminejad 2015 |
Iran | Case-control study | 18-45 years of age women with BMI<25 kg/m2 and without IGT in early follicular phase S: PCOS diagnosed with Rotterdam Criteria (n=98) C: systemically healthy women (n=98) |
196 | Pregnancy, smoking, malignancies, osteoporosis, BMI, IGT, thyroid diseases, hyperprolactinemia, Cushing’s syndrome, androgenic tumors, 21-hydroxylase deficiency, periodontal treatment or prophylactic antibiotic therapy during the past 6 months and hormonal effect of menstrual cycle | S:29.06±6.56 C:28.60±6.37 |
S: 23.81±4.10 C: 24.02±3.50 |
CAL,PD,%BOP, PI, tooth loss |
| Nair 2017 |
India | Case-control study | 18-45 years of age women having minimum of 20 teeth in early follicular phase S: PCOS diagnosed with Rotterdam Criteria (n=120) C: systemically healthy women (n=120) |
240 | Pregnancy, smoking, alcoholism, malignancy, osteoporosis, periodontal treatment or prophylactic antibiotic therapy during the past 6 months and hormonal effect of menstrual cycle | S: 23.40±4.47 C:23.6 ± 4.46 |
S: 24.39 ± 4.52 C: 22.09 ± 3.81 |
CAL,GI |